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Types There are five types of G6PD deficiency, based on the activity of the G6PD enzyme in your body ( Class 1: less than 10% G6PD enzyme activity with chronic hemolytic anemia, meaning that red blood cells are broken down quicker than they’re replenished Class 2: 10% or less G6PD enzyme activity with the breakdown of red blood cells only when you’re exposed to trigger foods, medications, or infections Class 3: 10%–60% G6PD enzyme activity, with symptoms appearing only in response to infections Class 4: more than 60% G6PD enzyme activity, with only mild symptoms Class 5: higher G6PD enzyme activity compared with healthy individuals