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Proteomics analysis of differentiated hepatocyte-like cells The proteomes of iPSCs, GF-HLCs, SM-HLCs and controls (CTR) (HUH7, HEP3B, HEPG2, SNU398, PHHs) were analyzed by data-dependent acquisition mass spectrometry (DDA-MS) (Figure 3A)

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2,3-BPG concentration increases in the RBC during adaptation to high altitude, in chronic obstructive pulmonary disease, and in anemia, promoting the release of O 2 to tissues when the O 2 tension and saturation of hemoglobin is decreased in the lung