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4,12 End-of-dose failure and the "wearing off" phenomenon: In elderly persons, 30% of hospital admissions may be linked to drug-related problems, and falls leading to hospitalizations are especially likely in patients with PD, particularly those experiencing "wearing off," a loss of benefit from a dose of L-dopa that typically occurs after a few hours

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Subsequently, the introduction of short-chain fatty acids into the system serves to reinstate the integrity of the intestinal barrier and ameliorate systemic inflammation