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It also reduced insulin resistance by influencing PPAR alpha and gamma expression (16) and by modulating phosphorylation status of insulin receptors and downstream signaling molecules (17)

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SBP2 binding to SECIS elements is thought to facilitate interactions with Sec elongation factor (eEF sec ) (117) and specific Sec tRNA (tRNA sec ) that are necessary for Sec incorporation (364, 403) (Fig