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While it is well known that enhanced insulin sensitivity and low insulin levels are associated with an improved survival, there is evidence showing that attenuation of growth hormone/IGF-1 axis may have beneficial effects in extending lifespan in humans

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— Comparison of Long R3 IGF-1 with Insulin in the Support of CHO Cell Growth and Recombinant Protein Expression — Repligen Scientific Poster IGF-1 LR3 vs Other IGF-1 Research Analogues IGF-1 LR3’s combination of prolonged half-life, broad IGFBP evasion, full receptor agonism, and extensive published validation across diverse research models makes it the preferred IGF-1 analogue where sustained, systemic IGF-1R engagement is the experimental objective