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The renoprotective effect of Nrf2 activation in systemic Keap1-KD mice is nicely recapitulated in a gene-modified mouse line in which the Keap1 gene is deleted exclusively in adult renal tubular cells (Table 1 and Figure 3A) [67]
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SOD1 in the cytosol converts NOX-generated O 2 − to H 2 O 2
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