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Vitamin B12 shots may not be suitable for people with a history of: sensitivity to vitamin B12 Leber’s disease, which affects the optic nerve kidney problems hypokalemia (low potassium levels) deficiencies in other nutrients, particularly folic acid and iron Vitamin B12 injections typically begin to work straight away

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Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 2–3 months, as it seems to have better retention than cyanoB 12