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also observed similar phenomena in the testes of STZ-induced diabetic mice and HG-treated GC-1spg cells, and found that BRD7 inhibits Clusterin expression by regulating hypermethylation of the Clusterin promoter in an EZH2-dependent manner, thereby suppressing AMPK signaling to promote ferroptosis and induce DM-related testicular injury [178]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Jocken J.W.E., Smit E., Goossens G.H., Essers Y.P.G., van Baak M.A., Mensink M., Saris W.H.M., Blaak E.E