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reported that ferroptosis in hepatocytes and intrahepatic macrophages may be the incentive for early simple steatosis and the progression from NAFLD toward to NASH: hepatocyte ferroptosis precedes apoptosis during the initial stages of NAFLD in model mice, leading to liver damage, immune cell infiltration, and inflammatory response ( 2+ and AA may act jointly to promote lipid peroxidation and NASH

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