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3.5 CB-839 induces autophagy in CLL cell lines Because glutamine flux regulates mammalian target of rapamycin complex 1’s kinase activity, which is responsible for autophagy, we assessed the effects of glutaminase inhibition on autophagy as an alternative mechanism of CB-839–mediated cell death ( Figure 4A )

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Epithalon is used in cell-based research examining its interactions with telomerase reverse transcriptase (TERT) activity and telomere length dynamics in cell culture models