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Although the heavy subunit by itself can catalyze the formation of L-γ-glutamyl-L-cysteine, binding with the modifier subunit enhances the enzyme activity by lowering the Km for glutamate and ATP, and increasing the Ki for GSH inhibition

C-BRIGHT-LIMIT

10MG:79

16 Despite increases in NAC concentrations, there was no observed increase in CSF total or reduced GSH concentrations, presumably because the conversion of NAC to GSH occurs intracellularly