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233 Sodium-glucose cotransporter-2 (SGLT2) inhibitors are commonly used for type 2 diabetes treatment, and in recent years, SGLT2 inhibitors canagliflozin has been shown to suppress IL-6 and IL-1β levels and MPO enzyme activity in the colon of UC rats by downregulating the expression of NF-κB p65, thereby reducing colonic inflammatory cell infiltration and oxidative stress
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The fluidity of the lipid bilayer is an important parameter of liposomes, which affects the release of active substances from the phospholipid systems and the ability to retain them inside the carrier as well as the skin permeation [61,62]
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