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Defects occur in both the NADPH oxidase complex itself and the enzymes of the PPP that yield the required NADPH, particularly G6PDH The Pentose Phosphate Pathway The pentose phosphate pathway (PPP) (also called hexose monophosphate shunt, HMS) consists of series of interconnected reactions that serve as an alternate route for the metabolism of glucose

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In the first step, the investigator should determine whether the patient has a multidrug-resistance phenotype associated with GST overexpression or carries a GST null genotype