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Interestingly, MHC-I expression in neurons has been reported to play a positive role in the development of synaptic plasticity and axonal regeneration (Cullheim and Thams, 2010), although other studies suggest that constitutive expression of MHC-I in neurons may be involved in neurodegenerative disorders by enhancing T cell-mediated CNS degeneration (Cebrián et al., 2014)