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Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons

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GSTs catalyze the conjugation of acrolein to GSH and the corresponding conjugate is further modified by the enzymatic cleavage of the GSH glutamic acid and glycine residues by γ-glutamyltranspeptidase and cysteinylglycinase, respectively