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An early multicenter, randomized, placebo-controlled study in individuals with AD of moderate severity found that supplementation with 2,000 IU/day of all - rac -α-tocopherol (equivalent to 900 mg/day of RRR -α-tocopherol) for two years significantly delayed cognitive decline, slowed disease progression, and increased median survival (107)

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ICP34.5 disrupts retinoic-acid-inducible gene I (RIG-I) signaling preventing interaction between RIG-I and mitochondrial antiviral signaling protein (MAVS), a pivotal adaptor inhibiting downstream activation IRF3 and subsequent IFN production ( Additionally, ICP34.5 impedes autophagic processes through Beclin binding interactions specifically targeting Beclin-1 (Atg6) ( Lastly, ICP34.5 also disrupts NF-kB activation suppressing dendritic maturation and ultimately impairing effective adaptive immunity against infection